Electrochemical Behavior of Valsartan, Glimepiride and Their Interaction with Each Other Using Square Wave Voltammetry

Abstract

In this work an electrochemical quantification and interaction of valsartan and glimepiride were studied on hanging mercury drop electrode (HMDE) using square wave voltammetric (SWV) technique. The effect of temperature on the interaction was investigated in eight degrees of heat and the thermodynamics parameters (enthalpy, entropy & free gibbs energy) were calculated for the interaction using Van't Hoff equation and binding constant (K) also obtained from interaction equation. From the values of the calculated thermodynamic parameters it found that the main bonding forces that predominated over the interaction were Vander Waals and Hydrogen bonding. The calibration curves of each drug was liner with R2 value equal to 0.9819, 0.997 and the limit of detection was found to be 4.99 x 10-7, 3.48 x 10-8 for valsartan and glimepiride respectively. Through the limit of detection, this method can be used as a standard method in estimating the pharmacists in pharmaceutics and verifying the credibility of the manufacturers of the two drugs.